Mitochondrial matrix pH as a decisive factor in neurometabolic imaging
نویسندگان
چکیده
منابع مشابه
Mitochondrial matrix pH as a decisive factor in neurometabolic imaging.
Alterations of cellular bioenergetics are a common feature in most neurodegenerative disorders. However, there is a selective vulnerability of different brain regions, cell types, and even mitochondrial populations to these metabolic disturbances. Thus, the aim of our study was to establish and validate an in vivo metabolic imaging technique to screen for mitochondrial function on the subcellul...
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Mitochondrial DNA (mtDNA) is highly polymorphic, and its variations in humans may contribute to individual differences in function as well as susceptibility to various diseases such as Parkinson disease, Alzheimer disease, bipolar disorder, and cancer. However, it is unclear whether and how mtDNA polymorphisms affect intracellular function, such as calcium signaling or pH regulation. Here we se...
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ژورنال
عنوان ژورنال: Neurophotonics
سال: 2017
ISSN: 2329-423X
DOI: 10.1117/1.nph.4.4.045004